Hyaluronidase (Hylenex)

How It Works

Hyaluronidase (Hylenex) is a purified enzyme that hydrolyzes the bonds within hyaluronic acid (HA), breaking down the filler matrix and allowing the body to rapidly absorb and clear the dissolved material. The result is a controlled, targeted reversal of HA-based dermal filler.

When It Is Used

This treatment is indicated in specific clinical situations, including:

• Overfilled areas requiring volume reduction
• Filler migration beyond the intended treatment zone
• Visible asymmetry or undesirable aesthetic outcomes
• Vascular occlusion — a medical emergency requiring immediate intervention

Hyaluronidase is not offered as a routine refinement or touch-up service. It is reserved for cases where clinical correction is necessary.

Results Timeline

Dissolution begins within minutes to hours of injection. The full effect of the treatment is typically visible within 24 to 48 hours as the body completes absorption of the broken-down filler material.

Potential Side Effects

As with any injectable treatment, some side effects may occur. These can include:

• Swelling and redness at the injection site
• Bruising
• Temporary volume loss beyond the targeted area
• Rare allergic reaction

Post-Treatment Guidance

Patients should wait a minimum of 2 weeks after hyaluronidase treatment before considering new filler injections. This allows the enzyme activity to fully resolve and the tissue to stabilize, ensuring accurate assessment of the treated area.

Important Note

Hyaluronidase is effective only on hyaluronic acid-based fillers. It does not dissolve non-HA fillers such as calcium hydroxylapatite (Radiesse), poly-L-lactic acid (Sculptra), or permanent fillers. Cost varies depending on the area treated and the amount of product required.